Package: RNOmni
Title: Rank Normal Transformation Omnibus Test
Version: 1.0.1.4
Date: 2024-11-09
Author: Zachary R. McCaw [aut, cre]
Maintainer: Zachary R. McCaw <zmccaw@alumni.harvard.edu>
Authors@R: person(given = "Zachary", family = "McCaw", role = c("aut", "cre"), email = "zmccaw@alumni.harvard.edu", comment = c(ORCID = "0000-0002-2006-9828"))
Description: Inverse normal transformation (INT) based genetic
        association testing. These tests are recommended for continuous
        traits with non-normally distributed residuals. INT-based tests
        robustly control the type I error in settings where standard
        linear regression does not, as when the residual distribution
        exhibits excess skew or kurtosis. Moreover, INT-based tests
        outperform standard linear regression in terms of power. These
        tests may be classified into two types. In direct INT (D-INT),
        the phenotype is itself transformed. In indirect INT (I-INT),
        phenotypic residuals are transformed. The omnibus test (O-INT)
        adaptively combines D-INT and I-INT into a single robust and
        statistically powerful approach. See McCaw ZR, Lane JM, Saxena
        R, Redline S, Lin X. "Operating characteristics of the
        rank-based inverse normal transformation for quantitative trait
        analysis in genome-wide association studies"
        <doi:10.1111/biom.13214>.
Depends: R (>= 3.2.2)
Imports: plyr, Rcpp, stats
LinkingTo: Rcpp, RcppArmadillo
License: GPL-3
URL: https://github.com/zrmacc/RNOmni
BugReports: https://github.com/zrmacc/RNOmni/issues
Encoding: UTF-8
RoxygenNote: 7.3.3
Suggests: testthat (>= 3.0.0), withr, R.rsp
VignetteBuilder: R.rsp
Config/testthat/edition: 3
Repository: https://zrmacc.r-universe.dev
Date/Publication: 2026-02-25 03:22:10 UTC
RemoteUrl: https://github.com/zrmacc/rnomni
RemoteRef: HEAD
RemoteSha: abd120809a5764db5f879a6b631a3b240a87aa23
NeedsCompilation: yes
Packaged: 2026-07-04 06:41:08 UTC; root