Package: RNOmni 1.0.1

RNOmni: Rank Normal Transformation Omnibus Test

Inverse normal transformation (INT) based genetic association testing. These tests are recommend for continuous traits with non-normally distributed residuals. INT-based tests robustly control the type I error in settings where standard linear regression does not, as when the residual distribution exhibits excess skew or kurtosis. Moreover, INT-based tests dominate standard linear regression in terms of power. These tests may be classified into two types. In direct INT (D-INT), the phenotype is itself transformed. In indirect INT (I-INT), phenotypic residuals are transformed. The omnibus test (O-INT) adaptively combines D-INT and I-INT into a single robust and statistically powerful approach. See McCaw ZR, Lane JM, Saxena R, Redline S, Lin X. "Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies" <doi:10.1111/biom.13214>.

Authors:Zachary McCaw [aut, cre]

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RNOmni.pdf |RNOmni.html
RNOmni/json (API)
NEWS

# Install 'RNOmni' in R:
install.packages('RNOmni', repos = c('https://zrmacc.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Bug tracker:https://github.com/zrmacc/rnomni/issues

Uses libs:
  • openblas– Optimized BLAS
  • c++– GNU Standard C++ Library v3

On CRAN:

6.42 score 2 packages 289 scripts 987 downloads 3 mentions 7 exports 3 dependencies

Last updated 2 years agofrom:7abc632921. Checks:OK: 1 NOTE: 8. Indexed: yes.

TargetResultDate
Doc / VignettesOKOct 12 2024
R-4.5-win-x86_64NOTEOct 12 2024
R-4.5-linux-x86_64NOTEOct 12 2024
R-4.4-win-x86_64NOTEOct 12 2024
R-4.4-mac-x86_64NOTEOct 12 2024
R-4.4-mac-aarch64NOTEOct 12 2024
R-4.3-win-x86_64NOTEOct 12 2024
R-4.3-mac-x86_64NOTEOct 12 2024
R-4.3-mac-aarch64NOTEOct 12 2024

Exports:BATDINTFitOLSIINTOINTOmniPRankNorm

Dependencies:plyrRcppRcppArmadillo

Rank Normal Omnibus Association Test

Rendered fromRNOmni.html.asisusingR.rsp::asison Oct 12 2024.

Last update: 2020-10-04
Started: 2020-10-04